Aksoy-Ozer ZB, Bitirim CV, Turan B, Akcali KC. The Role of Zinc on Liver Fibrosis by Modulating ZIP14 Expression Throughout Epigenetic Regulatory Mechanisms. Biol Trace Elem Res. 2024 Jan 15. doi: 10.1007/s12011-023-04057-5. PMID: 38221603.
Aktay I, Bitirim CV, Olgar Y, Durak A, Tuncay E, Billur D, Akcali KC, Turan B. Cardioprotective role of a magnolol and honokiol complex in the prevention of doxorubicin-mediated cardiotoxicity in adult rats. Mol Cell Biochem. 2023 Apr 19. doi: 10.1007/s11010-023-04728-w. PMID: 37074505.
Bitirim CV, Ozer ZB, Aydos D, Genc K, Demirsoy S, Akcali KC, Turan B. Cardioprotective effect of extracellular vesicles derived from ticagrelor-pretreated cardiomyocyte on hyperglycemic cardiomyocytes through alleviation of oxidative and endoplasmic reticulum stress. Scientific Reports. 2022 Apr 5;12(1):5651. doi: 10.1038/s41598-022-09627-6. PMID: 35383227; PMCID: PMC8983723.
Bitirim CV, Ozer ZB, Akcali KC. Estrogen receptor alpha regulates the expression of adipogenic genes genetically and epigenetically in rat bone marrow-derived mesenchymal stem cells. PeerJ 9:e12071. 2021. DOI: 10.7717/peerj.12071.
Bitirim CV. The role of zinc transporter proteins as predictive and prognostic biomarkers of hepatocellular cancer. PeerJ. 2021 Oct 15;9:e12314. doi: 10.7717/peerj.12314. PMID: 34721988; PMCID: PMC8522644.
Unal MA, Bitirim CV, Summak GY, Bereketoglu S, Cevher Zeytin I, Besbinar O, Gurcan C, Aydos D, Goksoy E, Kocakaya E, Eran Z, Murat M, Demir N, Aksoy Ozer ZB, Somers J, Demir E, Nazir H, Ozkan SA, Ozkul A, Azap A, Yilmazer A, Akcali KC. Ribavirin shows antiviral activity against SARS-CoV-2 and downregulates the activity of TMPRSS2 and the expression of ACE2 in vitro. Can J Physiol Pharmacol. 2021 May;99(5):449-460. doi: 10.1139/cjpp-2020-0734., 2021 Mar 9. PMID: 3.
Bitirim CV, Tuncay E,Turan B. Demonstration of subcellular migration of CK2α localization from nucleus to sarco(endo)plasmic reticulum in mammalian cardiomyocytes under hyperglycemia. Molecular and Cellular Biochemistry.2017, Oct 20. doi: 10.1007/s11010-017-3207-6.
Bitirim VC, Kucukayan-Dogu G, Bengu E, Akcali KC. Patterned carbon nanotubes as a new three-dimensional scaffold for mesenchymal stem cells. Mater Science and Engineering C. 2013, 1;33 (5):3054-60.
Aktay I, Bitirim CV, Olgar Y, Durak A, Tuncay E, Billur D, Akcali KC, Turan B. Cardioprotective role of a magnolol and honokiol complex in the prevention of doxorubicin-mediated cardiotoxicity in adult rats. Mol Cell Biochem. 2023 Apr 19. doi: 10.1007/s11010-023-04728-w. Epub ahead of print. PMID: 37074505.
Olgar Y, Durak A, Bitirim CV, Tuncay E, Turan B. Insulin acts as an atypical KCNQ1/KCNE1-current activator and reverses long QT in insulin-resistant aged rats by accelerating the ventricular action potential repolarization through affecting the β3 -adrenergic receptor signaling pathway. J Cell Physiol. 2022 Feb;237(2):1353-1371. doi: 10.1002/jcp.30597. Epub 2021 Oct 10. PMID: 34632595.
Durak A, Bitirim CV, Turan B. Titin and CK2 are new intracellular targets in acute insulin application associated benefits on electrophysiological parameters of left ventricular cardiomyocytes from insulin-resistant metabolic syndrome rats. Cardiovascular Drugs and Therapy,2020, doi: 10.1007/s10557-020-06969-z
Taheri H, Unal MA, Sevim M, Gurcan C, Ekim O, Ceylan A, Syrgiannis Z, Christoforidis KC, Bosi S, Ozgenç O, Gómez MJ, Turktas Erken M, Soydal Ç, Eroğlu Z, Bitirim CV, Cagin U, Arı F, Ozen A, Kuçuk O, Delogu LG, Prato M, Metin Ö, Yilmazer A.Photocatalytically Active Graphitic Carbon Nitride as an Effective and Safe 2D Material for In Vitro and In Vivo Photodynamic Therapy, SMALL, 2020, 1613-6810, doi:10.1002/smll.201904619
Tuncay E, Olgar Y, Durak A, Degirmenci S, Bitirim CV, Turan B. β3 -adrenergic receptor activation plays an important role in the depressed myocardial contractility via both elevated levels of cellular free Zn2+ and reactive nitrogen species.(Journal of Cellular Physiology. 20,9 Jan 5. doi: 10.1002/jcp.28015)
Olgar Y, Durak A, Tuncay E, Bitirim CV, Ozcinar E, Inan MB, Tokcaer-Keskin Z, Ozdemir S, Akcali KC, Akar AR, Turan B. Increased Cytosolic Free Zn2+ Correlates an Induction of Sarco(endo)plasmic Reticulum Stress via Altered Expression Levels of Zn2+-transporters in Heart Failure. Journal of Cellular and Molecular Medicine. 2018, Jan 15. doi: 10.1111/jcmm)
Tuncay E, Bitirim CV, Olgar Y, Durak A, Akar RA, Rutter G, Turan B. Zn2+-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes. (Mitochondrion. 2018, Jan 4. pii: S1567-7249(17)30261-1. doi: 10.1016/j.mito.2017.12.011)
Tuncay E, Bitirim VC, Durak A, Carrat G.R. J, Taylor K , Rutter G ,Turan B. Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart.Diabetes. 2017, pii: db161099. doi: 10.2337/db16-1099.
Arora H, Boulberda M, Qureshi R, Bitirim V, Gasser A, Messaddeq N, Dolle P, Nebigil CG. Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development. Scientific Reports. 2016, 6:25541. doi: 10.1038/srep25541.
Arora H, Boulberda M, Qureshi R, Bitirim V, Messaddeq N, Dolle P, Nebigil H. Prokineticin receptor-1 is required for Mesenchymal-Epithelial-Transition in kidney development. FASEB J. 2016, pii: fj.201600181R.
Kucukayan-Dogu G, Gözen D, Bitirim VC, Akcali KC, Bengu E. A New Tool for Differentiating Hepatocellular Cancer Cells: Patterned Carbon Nanotube Arrays. Applied Surface Science. 2015, 351:27-32.
Bayramoglu G, Bitirim VC, Arıca MY. Poly (hyroxyethyl methacrylate-glycidyl methacrylate) films modified with different functional groups: In vitro interactions with platelets and rat stem cells. Mater Science and Engineering C. 2013, 33(5):3054-60.